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26 results

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Expression Levels of Three Key Genes CCNB1, CDC20, and CENPF in HCC Are Associated With Antitumor Immunity.
Si T, Huang Z, Jiang Y, Walker-Jacobs A, Gill S, Hegarty R, Hamza M, Khorsandi SE, Jassem W, Heaton N, Ma Y. Si T, et al. Front Oncol. 2021 Sep 30;11:738841. doi: 10.3389/fonc.2021.738841. eCollection 2021. Front Oncol. 2021. PMID: 34660300 Free PMC article.
In the HCC microenvironment, the transcript levels of these three genes and inhibitory checkpoint molecules including PD-1, CTLA-4, and TIM-3 were positively correlated. CONCLUSION: The upregulation of CCNB1, CDC20, and CENPF genes was a common event in hepatocarcin …
In the HCC microenvironment, the transcript levels of these three genes and inhibitory checkpoint molecules including PD-1, CTLA-4, and TIM- …
Bioinformatics Analysis Highlight Differentially Expressed CCNB1 and PLK1 Genes as Potential Anti-Breast Cancer Drug Targets and Prognostic Markers.
Fang L, Liu Q, Cui H, Zheng Y, Wu C. Fang L, et al. Genes (Basel). 2022 Apr 7;13(4):654. doi: 10.3390/genes13040654. Genes (Basel). 2022. PMID: 35456460 Free PMC article.
Followed with WGCNA, PPI analysis, GEPIA 2, and HPA database verification, thirteen hub genes including CDK1, BUB1, BUB1B, CDC20, CCNB2, CCNB1, KIF2C, NDC80, CDCA8, CENPF, BIRC5, AURKB, PLK1, MAD2L1, and CENPE were obtained, and they may serve as potential therapeut …
Followed with WGCNA, PPI analysis, GEPIA 2, and HPA database verification, thirteen hub genes including CDK1, BUB1, BUB1B, CDC20, CCN …
Transcriptome analysis revealed CENPF associated with glioma prognosis.
Zhang M, Zhang Q, Bai J, Zhao Z, Zhang J. Zhang M, et al. Math Biosci Eng. 2021 Mar 2;18(3):2077-2096. doi: 10.3934/mbe.2021107. Math Biosci Eng. 2021. PMID: 33892537 Free article.
Identification of hub genes in the core module using the CytoHubba plugin. The top modular genes AURKA, CDC20, CDK1, CENPF, and TOP2A were associated with glioma development and prognosis. In the Human Protein Atlas (HPA) database, CDC20, CENPF and TOP …
Identification of hub genes in the core module using the CytoHubba plugin. The top modular genes AURKA, CDC20, CDK1, CENPF, an …
Loss of CENPF leads to developmental failure in mouse embryos.
Zhou CJ, Wang XY, Han Z, Wang DH, Ma YZ, Liang CG. Zhou CJ, et al. Cell Cycle. 2019 Oct;18(20):2784-2799. doi: 10.1080/15384101.2019.1661173. Epub 2019 Sep 3. Cell Cycle. 2019. PMID: 31478449 Free PMC article.
To further assess CENPF function in parthenogenetic or fertilized embryos development, morpholino (MO) and Trim-Away were used to disturb CENPF function. ...Disturbing of CENPF with Trim-Away approach in zygotes resulted in impaired development of 2-cell and …
To further assess CENPF function in parthenogenetic or fertilized embryos development, morpholino (MO) and Trim-Away were used to dis …
An integrated analysis of prognostic and immune infiltrates for hub genes as potential survival indicators in patients with lung adenocarcinoma.
Xu Z, Wang S, Ren Z, Gao X, Xu L, Zhang S, Ren B. Xu Z, et al. World J Surg Oncol. 2022 Mar 30;20(1):99. doi: 10.1186/s12957-022-02543-z. World J Surg Oncol. 2022. PMID: 35354488 Free PMC article.
DEGs in the subnetwork with the largest number of genes were AURKB, CCNB2, CDC20, CDCA5, CDCA8, CENPF, and KNTC1. The seven hub genes were highly expressed in LUAD tissues and were associated with poor prognosis. These hub genes were negatively correlated with most …
DEGs in the subnetwork with the largest number of genes were AURKB, CCNB2, CDC20, CDCA5, CDCA8, CENPF, and KNTC1. The seven hu …
Aberrantly DNA Methylated-Differentially Expressed Genes and Pathways in Hepatocellular Carcinoma.
Cai C, Wang W, Tu Z. Cai C, et al. J Cancer. 2019 Jan 1;10(2):355-366. doi: 10.7150/jca.27832. eCollection 2019. J Cancer. 2019. PMID: 30719129 Free PMC article.
Conclusions: In summary, the present study implied possible aberrantly methylated-differentially expressed genes and dysregulated pathways in HCC by bioinformatics analysis and experiments, which could be helpful in understanding the molecular mechanisms underlying the developmen …
Conclusions: In summary, the present study implied possible aberrantly methylated-differentially expressed genes and dysregulated pathways i …
Single-Cell Transcriptomics Identifies a Unique Entity and Signature Markers of Transit-Amplifying Cells in Human Corneal Limbus.
Li JM, Kim S, Zhang Y, Bian F, Hu J, Lu R, Pflugfelder SC, Chen R, Li DQ. Li JM, et al. Invest Ophthalmol Vis Sci. 2021 Jul 1;62(9):36. doi: 10.1167/iovs.62.9.36. Invest Ophthalmol Vis Sci. 2021. PMID: 34297801 Free PMC article.
The top genes were characterized morphologically and functionally at protein and mRNA levels. The specific expression patterns of RRM2, TK1, CENPF, NUSAP1, UBE2C, and CDC20 were well correlated in a time- and cycle-dependent manner with proliferation stages in the c …
The top genes were characterized morphologically and functionally at protein and mRNA levels. The specific expression patterns of RRM2, TK1, …
Bioinformatics analysis to reveal key biomarkers for early and late hepatocellular carcinoma.
Xi S, Zhao X, Liu W, Wang Y, Cao J, Liu B, Dou J. Xi S, et al. Transl Cancer Res. 2020 Jul;9(7):4070-4079. doi: 10.21037/tcr-19-2238. Transl Cancer Res. 2020. PMID: 35117777 Free PMC article.
Base on the protein-protein interaction network, CDK1, AURKA, CDC20, PLK1, AURKB, HIST1H2BG, BUB1B, CCNA2, CCNB1 and CDT1 were key protein. ...Overall, the confirmation results of qRT-PCR were generally consistent with our integrated analysis. CONCLUSIONS: A total of 4 DEm …
Base on the protein-protein interaction network, CDK1, AURKA, CDC20, PLK1, AURKB, HIST1H2BG, BUB1B, CCNA2, CCNB1 and CDT1 were key pr …
Screening of Key Prognosis Genes of Lung Adenocarcinoma Based on Expression Analysis on TCGA Database.
Shen Y, Tang X, Zhou X, Yi Y, Qiu Y, Xu J, Tian X. Shen Y, et al. J Oncol. 2022 Dec 26;2022:4435092. doi: 10.1155/2022/4435092. eCollection 2022. J Oncol. 2022. PMID: 36600965 Free PMC article. Retracted.
RESULTS: A total of 1,598 differential genes were identified through differential analyses and data mining, with 1,394 genes upregulated and 204 downregulated. A total of 10 hub genes CCNA2, CDC20, CCNB2, KIF11, TOP2A, BUB1, BUB1B, CENPF, TPX2, and KIF2C were obtain …
RESULTS: A total of 1,598 differential genes were identified through differential analyses and data mining, with 1,394 genes upregulated and …
Identification of Core Genes Shared by Endometrial Cancer and Ovarian Cancer Using an Integrated Approach.
Ke Y, Zhuang X, You L. Ke Y, et al. Cell Mol Biol (Noisy-le-grand). 2022 Sep 30;68(9):140-145. doi: 10.14715/cmb/2022.68.9.22. Cell Mol Biol (Noisy-le-grand). 2022. PMID: 36905262
We found that 154 common DEGs shared by OC and EC were also detected. 10 hub proteins were identified as follows: CDC20, BUB1, CENPF, KIF11, CCNB2, FOXM1, TTK, TOP2A, DEPDC1, and NCAPG. ...
We found that 154 common DEGs shared by OC and EC were also detected. 10 hub proteins were identified as follows: CDC20, BUB1, CEN …
26 results